There’s a very provocative new study in Lancet which may change my clinical practice. As parents know, vaccines are not a fun time for their children, and many doctors recommend pain medicines like Tylenol or Motrin with the vaccines. Now, unfortunately, there is good data from this new study that Tylenol (AKA acetaminophen, Panadol) may be blunting a very important biological immune response which helps to create protective antibodies. It seems that the low-grade fever after vaccines is crucial for stimulating our healthy immune response, and Tylenol is blocking that. Their conclusion:
Although febrile reactions significantly decreased, prophylactic administration of antipyretic drugs at the time of vaccination should not be routinely recommended since antibody responses to several vaccine antigens were reduced.
Article abstract: Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials : The Lancet.
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